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500 RL On-Line

500 Series

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500 RL On-Line Vision Teknik

We invite you to watch a two-minute video to see why simple is a smarter decision… Or click on the icon on the right.

Simplicity Information Sheets

Download our information sheets on how simplicity can help streamline your implementation of the 500 RL Analyzer:

  • Sievers On-line TOC – Simple is Smarter
  • Summary Sheet – Documentation that Supports the 500 RL

A Sievers 500 RL Analyzer can be configured for your intended use!

The 500 RL On-line TOC Analyzer can be configured and upgraded with a few hardware and software options at any time.

Reference Standard Introduction Devices

Super iOS – The four vial port Super-iOS fully automates all validation protocols, including system suitability testing and calibration. Reference standards come in an innovative cartridge, which is easily inserted into the Super iOS. Pressing start on the display menu initiates a protocol, with no further user action required. Each vial set cartridge includes an embedded memory chip that transfers standards data, including type, concentration, lot number, and expiration date to the 500 RL Analyzer.

Standard iOS – The single-port standard iOS is designed to allow the instrument to easily switch between online and vial sampling with no re-plumbing required. The standard iOS can perform all system protocols, just like the Super iOS, only one vial at a time.

On-line Conductivity

The 500 RL Analyzer is not only the most robust and easy to implement TOC analyzer available, but it is also a fully compliant on-line conductivity instrument. Raw conductivity and temperature data are available to support global regulatory requirements. The instrument even includes built-in USP/EP/JP conductivity “look-up” charts for Stage 1 testing. The Analyzer constantly verifies compliance and can immediately notify an operator via alarm or Modbus TCP/IP outputs.

21 CFR Part 11 and Annex 11 Compliance

DataGuard – With the optional DataGuard option, the 500 RL Analyzer includes a broad range of functions designed to simplify 21 CFR Part 11 and Annex 11 compliance (electronic records and signatures).

DataShare – This PC-based program allows you to export the 500 RL’s encrypted data output via a USB port for viewing, sharing, and creating reports. Data cannot be modified, ensuring data security consistent with 21 CFR Part 11 and Annex 11 requirements.

Are you looking for support for your on-line TOC project?

GE has the luxury of working with thousands of pharmaceutical customers around the world. We gain critical insights and information on how companies are implementing on-line TOC. In order to be successful with an on-line TOC project, you need support and resources that are aligned with global regulations, follow industry best practices, and help simplify implementation.

Take advantage of the following resources to better understand how your peers in the industry are implementing on-line TOC:

The Engineer’s Insights Toolbox

Have a project that needs an on-line TOC instrument? We have you covered.

Here are some of the most commonly requested items that your peers are using for their projects:

  • 500 RL Engineering Drawings
  • Tour the 500 RL Analyzer
  • 500 RL Specifications
  • MODBUS Overview (From the 500 RL Manual)
  • A simple presentation to share with your engineering team
  • A straightforward project plan (template) for change control
  • A recent article about On-line TOC Analysis

TOP On-line TOC Downloads

Want to see what your peers are downloading from our website? Here are the top On-line TOC downloads:

  • RL Installation Package Information
  • Sievers On-line TOC – Simple is Smarter
  • Summary Sheet – Documentation that Supports the 500 RL
  • Fact Sheet on the ASTM E55 2656 Standard Real Time Testing Using OLTOC

Regulations, Guiding Polices, Consensus Standards, Certificates, Conformity

View our links to industry and resources you may need to support your simple implementation of on-line TOC.

  • Engineering resources for procurement
  • Compliance with JP 16 TOC Requirements Using the Sievers 900 and 500 RL TOC Analyzers and Standards
  • Declarations of Conformity for the Sievers 500 RL TOC Analyzer base model and the Super iOS: 500 RL Base, 500 RL Super iOS

The Sievers 500 RL Analyzer is simply the most robust and easy to implement on-line TOC analyzer available.

TOC Analyzer Reliability – It simply measures TOC…nothing else!

The 500 RL TOC Analyzer combines an innovative design with the proven and trusted Sievers membrane TOC technology to ensure maximum uptime and reliability. While most on-line TOC technologies are limited to only ultra-low conductivity water, the 500 RL’s unique technology allows it to meaure TOC in water up to 25 uS/cm.

We invite you to learn more about the Sievers membrane TOC technology by watching this animation.

Conductivity Measurement

The 500 RL Analyzer is not only the most robust and easy to implement TOC analyzer available, but is also a fully compliant on-line conductivity instrument. Raw conductivity and temperature data are available to support global regulatory requirements. The instrument even includes built-in USP/EP/JP conductivity “look-up” charts for Stage 1 testing. The 500 RL constantly verifies compliance and can immediately notify an operator via alarm or Modbus TCP/IP outputs.

Easy to Use and Access Data

For several decades, the Sievers brand of TOC analyzers have been reliable and extremely easy to use. The 500 RL Analyzer is very user-friendly due to its automated calibration and suitability protocols. In addition, the 500 RL has a color touch-screen display that makes it easy to configure instrument parameters and view data in tabular or graphical form. The interface also provides real-time status of consumables, with prompts when semi-annual maintenance is due.

Low Maintenance and Operating Costs through Certified Plus

The 500 RL Analyzer does not use costly chemical consumables or catalysts and requires less than one hour per year of recommended preventive maintenance. The modular design makes consumables replacement fast and easy.

Do you prefer to have GE service your instruments? To help guarantee performance and ensure traceability for your Siever 500 RL TOC instrument, GE Analytical Instruments has developed the Certified Plus program. The Certified Plus suite of aftermarket products and services include traceable reference standards, quality parts, and highly trained technical support and field service personnel.

Innovative On-line Sampling System

The patented Sievers one-port Integrated On-Line Sampling System (iOS System)and innovative four-port Super iOS System fully automates all system protocols and can also analyze a quick grab sample for trouble shooting a specific port on your water system.

Traceability and simplicity go hand in hand when it comes to ensuring a quality measurement from an on-line TOC analyzer like the Sievers 500 RL. Reference standards are available to help you quickly and reliably perform the following regulatory tests:

USP/EP System Suitability JP System Suitability
Calibration Linearity
Robustness Specificity

Can’t find that unique standards set or kit? Feel free to download our standards and consumables brochure.

Total Organic Carbon*

Linear Range 0.03 to 2,500 ppb as C
Precision < 1% RSD or 0.03 ppb as C, whichever is greater
Accuracy ± 5% of measurement
pH Range 5.5 to 8.0 in order to meet accuracy specification
Analysis Modes On-line, on-line averaged, on-line timed
Analysis Time Continuous mode: 6 minutes
Average and timed modes: 0.5, 1, 4, 8, or 24 hours
Ozone Compatibility** Maximum 200 ppb as O3
External Flow Rate Minimum 50 mL/min
Sample Temperature 1–95 °C (34–203 °F)
Sample Pressure Up to 100 psig
Interferences Insensitive to organic heteroatoms
Calibration Stability Typically 12 months
Display Readout 3 significant digits

Conductivity*

Raw Conductivity Range*** 0.01 to 35 µS/cm
Conductivity Accuracy**** ± 0.005 µS/cm or ± 1%, whichever is greater
Conductivity Precision <0.25% RSD
Maximum Sample Conductivity 25 µS/cm at neutral pH

Instrument*

Power Universal Power Supply: 100–240 ± 10% VAC, 50 W, 50/60 Hz
Ambient Temperature 10–40°C (50–104°F)
Maximum Relative Humidity Up to 95%, noncondensing
Maximum Altitute 2,300 m (7,546 ft)
Inputs One isolated binary input
Outputs Three isolated 20mA outputs, one Serial RS-232 output, one USB port, one parallel printer port, and four alarm outputs
Installation/Overvoltage Category II (protects against transients present in Category II power)
Safety Certifications ETL, CE see Declaration of Conformity (base)
see Declaration of Conformity (Super iOS)
Pollution Degree 2 (normally only non-conductive pollution)
Display Backlit Quarter-VGA touchscreen display
Dimensions H: 41.9 cm (16.5 in); W: 48.3 cm (19 in); D: 27.4 cm (10.8 in)
Weight 16.9 kg (37.2 lb)
IP Rating Environmental Enclosure:  IP-45

* Stated analytical performance is achievable under controlled laboratory conditions that minimize operator and standards errors.
** The sample temperature and pressure should not simultaneously exceed 60 °C and 100 psi.
*** Ozone: 50 ppb continuous, conductivity accuracy ±0.02 µS/cm < 1.0 µS/cm, ±2% >1.0 µS/cm; 200 for 2 hours once/day, conductivity readings not within spec, recovery time to in-spec readings: 2 hours
**** With optional USP <645> conductivity measurement

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