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6200 Series Accurate Mass (TOF) LC/MS

Mass Spectrometry

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The TOF LC/MS system also supports MS/MS applications by using fragments formed in the desolvation region of the ion source. Using Agilent’s All Ions MS/MS software the TOF system enables compound identification by matching fragmentation patterns with an Agilent MS/MS library. Typical All Ions applications include toxicology analysis with an Agilent Personal Compound Library of 2,500 compounds and veterinary drug analysis using a library of over 600 compounds.

  • Reduce false positives with better than 1 ppm mass accuracy
  • Acquire data at 30 spectra per second to ensure excellent data quality for fast UHPLC peaks in high-throughput workflows
  • Confidently identify small molecules based on accurate mass and isotopic abundance and chemical composition using Find by Formula in MassHunter software.
  • Separate target compounds from interferences with mass resolution of greater than 22,000
  • Find impurities at extremely low concentrations – Agilent Jet Stream technology provides low picogram on-column sensitivity
  • Identify trace level target compounds – in the presence of more abundant matrix compound – with up to 5 orders of in spectrum dynamic range
  • Intuitive “walk-up” software makes the 6230B an ideal analytical tool for medicinal and synthetic chemists as well as biologists.
  • New All Ions MS/MS Technique for Targeted and Untargeted Screening on TOF and Q-TOF LC/MS

Found In : Application | Date: Jun 27, 2014 | FileSize: 0.931 MB

Increasing Quality While Maintaining Efficiency in Drug Chemistry with DART-TOF MSAlabama Department of Forensics demonstrate a sample pre-screening method forensic analyses using the DART-TOF MS with continuous calibration.

Found In : Application | Date: Mar 26, 2014 | FileSize: 0.327 MB

Characterization of Glycosylation in the Fc Region of Therapeutic Recombinant Monoclonal AntibodyFast and efficient LC TOF/MS characterizes intact and digested IgG to identify glycoform masses and profiles. mAb-glyco chip analysis built a glycan accurate mass database.

Found In : Application | Date: Apr 23, 2013 | FileSize: 0.459 MB

Peptide Mapping of Glycoprotein Erythropoietin by HILIC LC/MS and RP-LC-MSA comparison of the separation and sequence coverage of glycoproteins by reversed-phase and HILIC demonstrates the utility of HILIC.

Found In : Application | Date: Apr 22, 2013 | FileSize: 0.809 MB

High Resolution Glycopeptide Mapping of EPO Using an Agilent AdvanceBio Peptide Mapping ColumnThe AdvanceBio Peptide Mapping column gives 100% rhEPO sequence coverage with 45 glycopeptide matches.

Found In : Application | Date: Feb 14, 2013 | FileSize: 0.561 MB

Comprehensive Profiling of Free and Conjugated Estrogens by Capillary Electrophoresis-Time of Flight-Mass SpectrometryApplication note for comprehensive Profiling of Free and Conjugated Estrogens by Capillary Electrophoresis-Time of Flight-Mass Spectrometry

Found In : Application | Date: Feb 13, 2012 | FileSize: 0.754 MB

Using a Chlorine Filter for Accurate-Mass Data Analysis of Environmental SamplesApplication note for using a Chlorine Filter for Accurate-Mass Data Analysis of Environmental Samples

Found In : Application | Date: Dec 09, 2011 | FileSize: 1.032 MB

The LC/MS Walk-Up Solution from Agilent – MassHunter Easy Access softwareApplication note for the LC/MS Walk-Up Solution from Agilent – MassHunter Easy Access software

Found In : Application | Date: Jul 12, 2010 | FileSize: 0.983 MB

Pharmaceutical LC/MS Solutions from Agilent TechnologiesCompendium of applications applicable to the pharmaceutical industry, all run on LC/MS equipment.

Found In : Application | Date: Jun 28, 2010 | FileSize: 0.463 MB

Analysis of pharmaceuticals and drug related impurities using Agilent instrumentationApplication note for the analysis of pharmaceuticals and drug related impurities using Agilent instrumentation

Found In : Application | Date: May 11, 2010 | FileSize: 23.798 MB

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